A promising route to tackle the trade-off in cellular resources between synthetic protein production and cellular growth is to use a separate dedicated pool of orthogonal ribosomes to produce synthetic proteins. However, the optimisation of strains …
My work at Imperial on the quantitative characterisation and control of biological circuits for optimised microbial biotechnology applications.
This paper presents a generalisable method for the calibration of fluorescence readings on microplate readers, in order to convert arbitrary fluorescence units into absolute units. FPCountR relies on the generation of bespoke fluorescent protein (FP) …
Contributed abstract to the 14th International Workshop on Bio-Design Automation, Paris, France, October 24th-26th 2022.
My work at UCL on directed evolution methods, using bacterial surface display for xenobiology.
Directed evolution has been remarkably successful at expanding the chemical and functional boundaries of biology. That progress is heavily dependent on the robustness and flexibility of the available selection platforms, given the significant cost to …
Biocontainment comprises any strategy applied to ensure that harmful organisms are con- fined to controlled laboratory conditions and not allowed to escape into the environment. Genetically engineered microorganisms (GEMs), regardless of the nature …
Life on Earth is incredibly diverse. Yet, underneath that diversity, there are a number of constants and highly conserved processes- all life is based on DNA and RNA; the genetic code is universal; biology is limited to a small subset of potential …