My work at UCL on directed evolution methods, using bacterial surface display for xenobiology.
Directed evolution has been remarkably successful at expanding the chemical and functional boundaries of biology. That progress is heavily dependent on the robustness and flexibility of the available selection platforms, given the significant cost to …
Artificial metalloenzymes (ArMs hereafter) combine attractive features of both homogeneous catalysts and enzymes and offer the potential to implement new-to-nature reactions in living organisms. Herein we present an E. coli surface display platform …
Life on Earth is incredibly diverse. Yet, underneath that diversity, there are a number of constants and highly conserved processes- all life is based on DNA and RNA; the genetic code is universal; biology is limited to a small subset of potential …